Glipizide is an oral medium-to-long acting anti-diabetic drug from the sulfonylurea class. It is classified as a second generation Sulfonylurea, which means that it undergoes enterohepatic circulation.

Glipizide is commonly used to treat type 2 (noninsulin-dependent) diabetes (formerly 'adult-onset'), particularly in people whose diabetes cannot be controlled by diet alone.

Glipizide lowers blood sugar by stimulating the pancreas to secrete insulin and helping the body use insulin efficiently. The pancreas must be capable of producing insulin for this medication to work.

Glipizide is not used to treat type 1 (insulin-dependent) diabetes (formerly 'juvenile-onset').

NOTE: approximately 90% of patients with diabetes have type II or non-insulin dependent diabetes mellitus. Type II diabetes usually occurs in adulthood and is associated with obesity and a strong family history of diabetes. The inability to control the blood sugar (glucose) is caused by impaired insulin release by the pancreas and resistance to insulin by cells.

 

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